Cytological evidence for switches in polarity of chromosomal DNA.

نویسندگان

  • S Wolff
  • D L Lindsley
  • W J Peacock
چکیده

From the types of ring chromosomes induced in x-irradiated Chinese hamster ovary (CHO) cells, we deduce the existence of switches in the polarity of chromosomal DNA; if there is a continuous DNA double helix along the full length of the chromosome then the polarity switches imply 3'-3' and 5'-5' phosphodiester linkages. The resolution of the method is such that we estimate that there is one polarity switch for every 10(9) normal 3'-5' phosphodiester bonds.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 73 3  شماره 

صفحات  -

تاریخ انتشار 1976